[Significance of branched-chain keto acids for protein metabolism]

Branched chain keto acids may offer therapeutic benefits for clinical conditions associated with nitrogen accumulation or increased proteolysis. The effects of keto acids on protein metabolism are complex. Mechanisms such as (1) transamination to the respective amino acids, (2) inhibition of proteolysis, (3) stimulation of insulin secretion, and (4) augmentation in the activity of BCKA-decarboxylase need to be considered. Presently, therapy with branched chain keto acids is still experimental.