Bone biology and COVID-19 infection: Is ACE2 a potential influence factor?

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Huaqiang Tao1, Jiaxiang Bai1, Weicheng Zhang1

  • 1Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.

Medical Hypotheses
|December 1, 2020
PubMed

Insights

This study investigates if severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) causes bone lesions. It explores the virus

Area of Science:

  • Infectious Diseases
  • Orthopedics
  • Pathobiology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, presents a significant global health challenge.
  • Emerging research suggests potential links between SARS-CoV-2 infection and bone pathology.

Purpose of the Study:

  • To investigate the potential for bone lesions following SARS-CoV-2 infection.
  • To explore the pathobiology of how SARS-CoV-2 may affect bone remodeling.
  • To analyze the association between bone destruction and ACE2 in COVID-19.

Main Methods:

  • Review of existing literature on SARS-CoV-2 pathogenesis and bone remodeling.
  • Analysis of the role of Angiotensin-Converting Enzyme 2 (ACE2) in viral infection and bone metabolism.

Main Results:

  • SARS-CoV-2 may influence bone remodeling processes.
  • ACE2 receptors are implicated in both viral entry and potential bone destruction.

Conclusions:

  • Understanding the link between COVID-19 and bone lesions is crucial for orthopedic clinical management.
  • Further research is needed to elucidate the precise mechanisms of SARS-CoV-2-induced bone pathology.
Keywords:
ACE2Bone lesionCOVID-19SARS-COV-2

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