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Fabry disease patients have an increased risk of stroke in the COVID-19 ERA. A hypothesis

R C Reisin1, P Rozenfeld2, P Bonardo3

  • 1Neurology Service Hospital Britanico de Buenos Aires, Argentina; AADELFA Asociación Argentina de Estudio de Enfermedad de Fabry y otras Enfermedades Lisosomales.

Medical Hypotheses
|December 1, 2020
PubMed

Insights

Fabry disease (FD) patients with COVID-19 face a higher risk of stroke. Both conditions share similar harmful mechanisms, increasing cerebrovascular complications in infected individuals.

Area of Science:

  • Neurology
  • Vascular Biology
  • Infectious Diseases

Background:

  • Stroke is a common complication in Fabry disease (FD), resulting from complex mechanisms like endothelial dysfunction and inflammation.
  • These mechanisms create a prothrombotic state and increase the risk of cardioembolic stroke.

Purpose of the Study:

  • To analyze the overlapping pathogenic mechanisms between Fabry disease and COVID-19.
  • To hypothesize the increased risk of cerebrovascular complications in FD patients with SARS-CoV-2 infection.

Main Methods:

  • Review of existing literature on the pathophysiology of Fabry disease.
  • Analysis of pathogenic mechanisms associated with coronavirus disease 2019 (COVID-19).
  • Comparative analysis of shared deleterious pathways.

Main Results:

  • Both FD and COVID-19 involve endothelial dysfunction, inflammation, and a prothrombotic state.
  • These shared mechanisms suggest a potential for synergistic negative effects on cerebrovascular health.

Conclusions:

  • Fabry disease patients infected with SARS-CoV-2 may have a significantly elevated risk of both ischemic and hemorrhagic cerebrovascular events.
  • Further research is warranted to confirm and understand this heightened risk.

Keywords:
CardiopathyCovid-19Fabry diseasePathophysiologyStroke in the YoungVasculopathy

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