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Injectable, strong and bioadhesive catechol-chitosan hydrogels physically crosslinked using sodium bicarbonate.

Capucine Guyot1, Marta Cerruti2, Sophie Lerouge1

  • 1Dept of Mechanical Engineering, École de Technologie Supérieure, 1100 rue Notre-Dame Ouest, Montréal, QC H3C 1K3, Canada; Centre de Recherche du CHUM, 900 Rue Saint-Denis, Montréal, QC H2X 0A9, Canada.

Materials Science & Engineering. C, Materials for Biological Applications
|December 1, 2020
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Summary

Newly developed catechol-chitosan (cat-CH) hydrogels with sodium bicarbonate (SHC) offer rapid gelation and enhanced bioadhesion for drug delivery and cell therapy applications. These injectable materials show promising physiological compatibility and tissue adhesion.

Keywords:
BioadhesionBiomaterialsBiomimetismCatecholChitosanHydrogels

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Thermosensitive chitosan hydrogels are valuable for drug delivery and cell therapy.
  • Existing chitosan hydrogels often lack rapid gelation and sufficient bioadhesion for certain applications.

Purpose of the Study:

  • To design and characterize injectable, fast-gelling, and bioadhesive hydrogels based on modified chitosan.
  • To evaluate the potential of catechol-chitosan (cat-CH) and sodium bicarbonate (SHC) for creating advanced hydrogel matrices.

Main Methods:

  • Chitosan was modified with catechol (cat-CH).
  • Hydrogels were formed using cat-CH and sodium bicarbonate (SHC) as a gelling agent.
  • Gelation time, mechanical properties (secant modulus), tissue adhesion, pH, and osmolality were assessed.

Main Results:

  • Cat-CH/SHC hydrogels exhibited rapid gelation (< 5 minutes at 37°C).
  • Achieved a high secant modulus (90 kPa at 50% strain) after 24 hours.
  • Demonstrated significantly enhanced tissue adhesion compared to unmodified chitosan hydrogels.
  • Maintained physiological pH and osmolality.

Conclusions:

  • Catechol modification and sodium bicarbonate enable the creation of fast-gelling, injectable, and bioadhesive chitosan hydrogels.
  • These hydrogels possess desirable mechanical properties and physiological compatibility.
  • The unique combination of features suggests significant potential for drug and cell encapsulation, pending biocompatibility confirmation.