Related Experiment Video

Updated: Nov 28, 2025

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.8K

MicroRNA, Diabetes Mellitus and Colorectal Cancer

Hsiuying Wang1

  • 1Institute of Statistics, National Chiao Tung University, Hsinchu 30010, Taiwan.

Biomedicines
|December 1, 2020
PubMed

Insights

Diabetes mellitus (DM) and colorectal cancer (CRC) share common microRNA (miRNA) biomarkers. Understanding these shared miRNAs may reveal links between DM and CRC, aiding in the prevention of both diseases.

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Diabetes mellitus (DM) is a metabolic disorder affecting insulin production or response.
  • DM is linked to various complications, including cancers.
  • Colorectal cancer (CRC) is a major global cancer with rising incidence in younger populations.

Purpose of the Study:

  • To review the association between DM and CRC.
  • To explore common microRNA (miRNA) biomarkers linking DM and CRC.
  • To understand how shared miRNAs contribute to the correlation between DM and CRC.

Main Methods:

  • Literature review focusing on DM, CRC, and miRNA biomarkers.
  • Analysis of studies investigating shared miRNA functions in both diseases.
  • Synthesis of current knowledge on miRNA roles in DM and CRC pathogenesis.

Main Results:

  • miRNAs play crucial roles in cell regulation, including proliferation and apoptosis.
  • Specific miRNAs are implicated in both DM (glucose tolerance, insulin sensitivity) and CRC (tumor suppression).
  • Identifying common miRNA biomarkers offers insights into the underlying mechanisms connecting DM and CRC.

Conclusions:

  • Shared miRNA biomarkers represent a potential link between DM and CRC.
  • Further investigation into these common miRNAs can elucidate disease correlations.
  • Understanding these links may facilitate the development of preventative strategies for both DM and CRC.
Keywords:
biomarkerscolorectal cancerdiabetes mellitusglucoseinsulinmicroRNA

More Related Videos

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

180
miRNA Expression Analyses in Prostate Cancer Clinical Tissues11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.1K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.4K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.2K