Streptococcus gordonii: Pathogenesis and Host Response to Its Cell Wall Components
Ok-Jin Park1, Yeongkag Kwon1, Chaeyeon Park1
1Department of Oral Microbiology and Immunology, School of Dentistry, Dental Research Institute, Seoul National University, Seoul 08826, Korea.
Microorganisms
|December 1, 2020
Summary
Streptococcus gordonii cell wall components are key virulence factors. Understanding these components in Streptococcus gordonii can help develop new therapeutic strategies against opportunistic infections.
Area of Science:
- Microbiology
- Immunology
- Pathogenesis
Background:
- Streptococcus gordonii is a Gram-positive commensal bacterium.
- It is an opportunistic pathogen causing diseases like apical periodontitis and infective endocarditis.
- S. gordonii forms biofilms on host tissues and invades deeper tissues.
Purpose of the Study:
- To review the role of S. gordonii cell wall components in pathogenesis.
- To explore how these components contribute to disease development.
- To identify potential therapeutic strategies targeting these components.
Main Methods:
- Literature review of S. gordonii pathogenesis.
- Analysis of S. gordonii cell wall structure and function.
- Examination of host-pathogen interactions.
Main Results:
- S. gordonii cell wall components (lipoteichoic acids, lipoproteins, etc.) are recognized by host receptors.
- These components are involved in virulence and immune regulation.
- They contribute to inflammatory responses and disease progression.
Conclusions:
- S. gordonii cell wall components are significant virulence factors.
- Targeting these components offers potential for novel therapeutic interventions.
- Further research into these interactions can guide treatment development.
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