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Updated: Nov 28, 2025

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
Published on: November 17, 2023
The Genetic Complexity of Prostate Cancer
Eva Compérat1,2,3, Gabriel Wasinger3, André Oszwald3
1CeRePP/GRC5 Predictive Onco-Urology, Sorbonne University, 75020 Paris, France.
Abstract:
Prostate cancer (PCa) is a major concern in public health, with many genetically distinct subsets. Genomic alterations in PCa are extraordinarily complex, and both germline and somatic mutations are of great importance in the development of this tumor. The aim of this review is to provide an overview of genetic changes that can occur in the development of PCa and their role in potential therapeutic approaches. Various pathways and mechanisms proposed to play major roles in PCa are described in detail to provide an overview of current knowledge.
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