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Affinity Purification of Influenza Virus Ribonucleoprotein Complexes from the Chromatin of Infected Cells
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Role of microRNA and Oxidative Stress in Influenza A Virus Pathogenesis

Md Mamunul Haque1, Dhiraj P Murale1, Jun-Seok Lee1,2

  • 1Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.

International Journal of Molecular Sciences
|December 1, 2020
PubMed

Insights

This review explores the link between microRNAs (miRNAs) and oxidative stress (OS) in influenza A virus (IAV) infection. Understanding this interaction offers new diagnostic and therapeutic strategies for IAV.

Area of Science:

  • Molecular Biology
  • Virology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression involved in cellular pathways.
  • Influenza A virus (IAV) infection significantly impacts host cells, leading to oxidative stress (OS).
  • A complex interplay exists where miRNAs can influence OS, and OS can modulate miRNA expression during IAV infection.

Purpose of the Study:

  • To review the intricate crosstalk between miRNAs and OS during IAV infection.
  • To highlight the potential of miRNAs as diagnostic biomarkers for IAV.
  • To explore miRNAs as therapeutic targets for managing IAV infections.

Main Methods:

  • Literature review of existing research on miRNA-OS interactions in IAV.
  • Analysis of host-IAV interactions and their impact on oxidative balance.
  • Synthesis of current knowledge on miRNA regulation and OS pathways.

Main Results:

  • Evidence suggests a bidirectional relationship between miRNAs and OS during IAV pathogenesis.
  • Dysregulation of miRNAs and OS are critical factors in IAV infection severity.
  • miRNAs show promise as indicators and targets for IAV intervention.

Conclusions:

  • The crosstalk between miRNAs and OS is a crucial area for understanding IAV pathogenesis.
  • Targeting miRNA-OS interactions may lead to novel strategies for diagnosing and treating IAV infections.
  • Further research into host-virus interactions involving miRNAs and OS is warranted for developing new intervention methods.
Keywords:
influenza A virusmicroRNAoxidative stress

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