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Cancer Prevention by Natural Products Introduced into the Diet-Selected Cyclitols

Karol Wiśniewski1, Marcin Jozwik2, Joanna Wojtkiewicz1

  • 1Department Pathophysiology, School of Medicine, University of Warmia and Mazury, 10-082 Olsztyn, Poland.

International Journal of Molecular Sciences
|December 1, 2020
PubMed

Insights

Cyclitols show promise as safe and effective agents to prevent cancer and reduce treatment side effects. Supplementation may decrease cancer incidence, metastasis, and improve outcomes for lung, breast, colorectal, and prostate cancers.

Area of Science:

  • Oncology
  • Nutritional Science
  • Molecular Biology

Background:

  • Cancer is a leading global cause of death, with limited effective chemopreventive agents available.
  • Lung, breast, and colorectal cancers are among the most common malignancies worldwide.
  • Current treatments often have significant side effects, necessitating supportive therapies.

Purpose of the Study:

  • To comprehensively review the current knowledge on cyclitol supplementation in cancer treatment.
  • To evaluate the potential of cyclitols as chemopreventive agents and adjuncts to conventional therapies.
  • To focus on cyclitol efficacy in lung, breast, colorectal, and prostate cancers.

Main Methods:

  • Literature review of existing studies on cyclitols and cancer.
  • Analysis of preclinical and clinical data regarding cyclitol's effects on cancer cells and patients.
  • Synthesis of evidence on cyclitol's impact on cancer incidence, progression, and treatment side effects.

Main Results:

  • Cyclitol supplementation is associated with decreased colorectal cancer incidence and reduced metastasis risk.
  • Cyclitols demonstrate anti-proliferative effects, induce apoptosis in cancer cells, and enhance natural killer (NK) cell activity.
  • Evidence suggests cyclitols protect cells from free radical damage and mitigate chemotherapy/surgery side effects.
  • Cyclitol supplementation is generally safe and well-tolerated.

Conclusions:

  • Cyclitols represent a promising therapeutic strategy for various cancers, including lung, breast, colorectal, and prostate.
  • Their chemopreventive potential and ability to reduce treatment-related toxicity warrant further investigation.
  • Cyclitols may offer a safe and effective approach to improving cancer patient outcomes.
Keywords:
IP6cancerchemopreventioncyclitolsinositolplant foods

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