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RAGE Signaling in Melanoma Tumors

Olamide T Olaoba1, Sultan Kadasah1, Stefan W Vetter1

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, North Dakota State University, Fargo, ND 58105, USA.

International Journal of Molecular Sciences
|December 1, 2020
PubMed

Insights

The receptor for advanced glycation end products (RAGE) is crucial in melanoma progression. Targeting RAGE offers a potential strategy to improve outcomes for melanoma patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Dermatology

Background:

  • Malignant cutaneous melanoma has a poor prognosis despite treatment advances.
  • The receptor for advanced glycation end products (RAGE) is implicated in melanoma progression.
  • RAGE activation occurs in both cancer and stromal cells within tumors.

Purpose of the Study:

  • To review the current role of RAGE in melanoma.
  • To highlight the significance of RAGE ligands in melanoma progression.
  • To evaluate RAGE as a therapeutic target in melanoma.

Main Methods:

  • Literature review of RAGE in melanoma.
  • Analysis of RAGE activation pathways and ligands.
  • Synthesis of evidence on RAGE's role in tumor progression.

Main Results:

  • RAGE activation is a key driver of melanoma progression.
  • Numerous ligands, including S100B and HMGB1, fuel RAGE activation.
  • The roles of many RAGE ligands in melanoma are not fully understood.

Conclusions:

  • Targeting RAGE presents a promising therapeutic strategy for melanoma.
  • Further research into RAGE ligands could uncover new therapeutic avenues.
  • Modulating RAGE signaling may improve clinical outcomes for melanoma patients.
Keywords:
HMGB1RAGES100 proteinsinflammationmelanomamelanomagenesisreceptor for advanced glycation end productstumorigenesis

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