Related Experiment Video

Updated: Nov 28, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.1K

Controlled direct effect of psychiatric disorders on cardiovascular disease: evidence from a large Kurdish cohort

Zahra Darabi1, Farid Najafi2, Roya Safari-Faramani3

  • 1Department of Epidemiology, School of Public Health, Kermanshah University of Medical Sciences, 6719851351, Kermanshah, Iran.

BMC Cardiovascular Disorders
|December 1, 2020
PubMed

Insights

Psychiatric disorders increase cardiovascular disease risk. Even with good oral hygiene, this link persists, suggesting targeted interventions for mental health can improve heart health.

Area of Science:

  • Cardiovascular Health
  • Psychiatry
  • Public Health

Background:

  • Psychiatric disorders are strongly linked to cardiovascular diseases (CVD), mortality, and hospital readmissions.
  • Oral and dental hygiene may influence this association, warranting further investigation.
  • Understanding the direct impact of psychiatric conditions on CVD is crucial for effective public health strategies.

Purpose of the Study:

  • To evaluate the controlled direct effect of psychiatric disorders on cardiovascular diseases.
  • To assess the mediating role of oral and dental hygiene in the relationship between psychiatric disorders and CVD.
  • To investigate specific oral health indicators, including hygiene behaviors, oral lesions, and tooth decay, as potential mediators.

Main Methods:

  • Utilized data from the Ravansar Non-communicable Disease (RaNCD) cohort study, including 10,065 adults aged 35-65.
  • Employed a marginal structural model with stabilized inverse probability weights to estimate the controlled direct effect.
  • Analyzed three mediator models: oral/dental hygiene behaviors, oral ulcer/lesions, and decayed, missing, and filled teeth (DMFT).

Main Results:

  • Psychiatric disorders increased CVD odds by 83% (OR=1.83) and by approximately two times when controlling for hygiene behaviors and oral lesions.
  • When DMFT was considered (≤8), the controlled direct effect of psychiatric disorders on CVD was not statistically significant (OR=0.90).
  • A direct relationship between psychiatric disorders and CVD was observed, independent of oral hygiene status.

Conclusions:

  • Psychiatric disorders have a direct impact on cardiovascular diseases, irrespective of oral hygiene.
  • Interventions targeting individuals with psychiatric disorders may effectively reduce the prevalence of cardiovascular diseases.
  • Public health initiatives should consider the interplay between mental health and cardiovascular well-being.
Abstract

Keywords:
Cardiovascular diseaseControlled direct effectOral and dental hygienePsychiatric disorders

More Related Videos

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment08:25

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

693
Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

16.4K

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
198
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
688
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
484
Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
3.8K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.1K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
322