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Platelet proteome changes in dogs with congestive heart failure
Pinar Levent1, Meriç Kocaturk1, Emel Akgun2
1Department of Internal Medicine, Faculty of Veterinary Medicine, Bursa Uludag University, 16059, Bursa, Turkey.
BMC Veterinary Research
|December 1, 2020
Summary
Platelet protein changes were identified in dogs with congestive heart failure (CHF). This study reveals altered platelet proteomes in canine CHF, offering insights into disease mechanisms and potential therapeutic targets.
Area of Science:
- Cardiovascular Science
- Proteomics
- Canine Medicine
Background:
- Platelets are crucial in cardiovascular disease development.
- Platelet protein alterations are implicated in human heart disease pathophysiology.
- The role of platelets in canine congestive heart failure (CHF) is not well understood.
Purpose of the Study:
- To investigate global platelet proteome changes in dogs with CHF.
- To clarify the potential role of platelets in the physiopathology of canine CHF.
- To establish a baseline for understanding platelet function in canine heart disease.
Main Methods:
- Compared platelet proteomes of healthy dogs (n=10) with dogs experiencing acute CHF due to myxomatous mitral valve disease (MMVD, n=10).
- Utilized LC-MS based label-free differential proteome expression analysis.
- Identified and quantified proteins within canine platelet samples.
Main Results:
- Identified 104 distinct proteins in dog platelets.
- Observed significant up-regulation of 4 proteins and down-regulation of 6 proteins in acute CHF dogs.
- Noted changes in proteins involved in molecular functions, biological processes, and immune-inflammatory responses.
Conclusions:
- This study presents the first description of platelet protein composition changes in dogs with acute CHF secondary to MMVD.
- Findings enhance knowledge of canine platelet proteomes and their involvement in MMVD-induced CHF.
- Results provide a foundation for future research into the prevention and treatment of canine CHF.
