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NGS-based typings for 7 HLA loci in two populations from Barra Mansa, RJ, Brazil
Romulo Vianna1, Leonardo Hanhoerderster1, Juliana Cardoso1
1Laboratório de Histocompatibilidade e Criopreservação, Universidade do Estado do Rio de Janeiro, Avenida Marechal Rondon 381, 20950-003 Rio de Janeiro, Brazil.
Abstract:
We investigated HLA class I (HLA-A, -B, and -C) and class II (HLA-DRB1, -DQB1, -DPA1, and -DPB1) alleles by NGS-based typing among 478 Brazilian individuals from two populations in the Barra Mansa city based on their self-declared skin color (Caucasian, N = 405, AFND-ID: 3729; Black, N = 73, AFND-ID: 3731) to calculate allelic and haplotypic frequencies, plus linkage disequilibrium. No locus deviated from Hardy-Weinberg equilibrium. Both populations shared the most frequent allele on HLA-A, -C, -DPA1, and -DPB1. Genotype and frequency data are available in the Allele Frequencies Net Database.
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