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[Chromomycosis].

P Cachão1, M M Rocha, J Cabrita

  • 1Servico de Dermatologia, Hospital de, Santa Maria, Lisboa.

Medicina Cutanea Ibero-Latino-Americana
|January 1, 1987
PubMed
Summary
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A rare 25-year case of chromomycosis caused by Fonsecaea pedrosoi in Mozambique showed unexpected recovery. Combined amphotericin B and 5-fluorocytosine therapy, with topical heat, led to clinical improvement and fungal clearance.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Chromomycosis is a chronic fungal infection of the skin and subcutaneous tissue.
  • Fonsecaea pedrosoi is a common etiological agent of chromomycosis, particularly in tropical and subtropical regions.
  • Long-standing and extensive chromomycosis cases often present poor prognoses and therapeutic challenges.

Observation:

  • A 57-year-old male in Mozambique presented with a 25-year history of chromomycosis.
  • Lesions were extensive and fibrotic, indicating a chronic and severe disease course.
  • Previous treatments with 5-fluorocytosine and ketoconazole were unsuccessful.

Findings:

  • Isolation of Fonsecaea pedrosoi confirmed the causative agent.
  • A combination therapy of amphotericin B and 5-fluorocytosine, alongside topical heat, was administered.

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  • The patient achieved clinical improvement and negative mycological studies post-treatment.

    • Implications:

    • This case highlights a successful therapeutic strategy for chronic and extensive chromomycosis.
    • The combination of systemic antifungals and topical heat may be effective in refractory cases.
    • Further research into optimal treatment protocols for advanced chromomycosis is warranted.