Left ventricular myocardial oxygen demand and subclinical dysfunction in patients with severe obesity referred for...

Increased myocardial oxygen (O₂) demand carries higher cardiovascular risk in hypertension. We hypothesized that myocardial O₂ demand is increased in severe obesity and linked to early left ventricular (LV) dysfunction.

Baseline data from 106 severely obese subjects referred for gastric bypass surgery (42 ± 11 years, 74% women, body mass index [BMI] 41.9 ± 4.8 kg/m², 32% with hypertension) in the prospective FatWest (Bariatric Surgery on the West Coast of Norway) study was used. LV systolic function was assessed by biplane ejection fraction (EF), midwall shortening (MWS) and endocardial global longitudinal strain (GLS), and LV diastolic function by mitral annular early diastolic velocity (e'). Myocardial O₂ demand was estimated from the LV mass-wall stress-heart rate product (high if > 1.62 × 10⁶/2.29 × 10⁶ g kdyne/cm² bpm in women/men). High myocardial O₂ demand was found in 33% and associated with higher BMI and high prevalence of low GLS (65%) and low MWS (63%) despite normal EF. In ROC analyses, higher myocardial O₂ demand discriminated between patients with low vs. normal MWS and GLS (area under curve 0.71 and 0.63, p < 0.05). In successive multiple regression analyses, higher myocardial O₂ demand was associated with lower LV MWS, GLS and average e', respectively, independent of age, gender, BMI, pulse pressure, diabetes mellitus, and EF (all p < 0.05).

In obese patients without known heart disease and with normal EF referred for bariatric surgery, high myocardial O₂ demand is associated with lower myocardial function whether assessed by GLS or MWS independent of confounders. CLINICALTRIALS.

NCT01533142.