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Updated: Nov 28, 2025

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Gamma heavy chain disease complicated by pulmonary hypertension, which was successfully treated with lenalidomide

Sho Shibata1, Akiko Fukunaga2

  • 1Hematology, Tazuke Kofukai, Medical Research Institute, Kitano Hospital, Osaka, Japan ashitaharerukana21@gmail.com.

BMJ Case Reports
|December 1, 2020
PubMed

Insights

This study reports a rare case of gamma heavy chain disease (HCD) in a patient with pulmonary hypertension. Lenalidomide and dexamethasone therapy demonstrated long-term disease control, marking a potential new treatment option.

Area of Science:

  • Hematology
  • Oncology
  • Rare Diseases

Background:

  • Heavy chain disease (HCD) is a rare B-cell neoplasm characterized by truncated immunoglobulin heavy chains.
  • Gamma HCD is a specific subtype, often presenting with nonspecific symptoms.
  • Pulmonary hypertension is a serious complication that can affect patient prognosis.

Keywords:
haematology (incl blood transfusion)oncology

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