Related Experiment Video

Updated: Nov 28, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.1K

Risk factors for myopia at 1-year corrected age following laser photocoagulation for retinopathy of prematurity

Yujiro Mori1, Mitsuru Arima2, Emi Ueda1

  • 1Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Eye (London, England)
|December 1, 2020
PubMed

Insights

High laser spot counts during retinopathy of prematurity (ROP) treatment in preterm infants are linked to myopia development. This finding highlights a potential factor influencing visual outcomes in these vulnerable infants.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Pediatric Medicine

Background:

  • Preterm infants undergoing laser photocoagulation (LPC) for retinopathy of prematurity (ROP) exhibit a higher prevalence of myopia.
  • Understanding factors contributing to myopia in this population is crucial for early intervention and management.

Purpose of the Study:

  • To investigate clinical factors associated with the development of myopia in preterm infants treated with LPC for ROP.
  • To identify specific treatment-related variables that correlate with refractive errors in this high-risk group.

Main Methods:

  • Retrospective analysis of medical records of preterm infants (≤32 weeks gestational age or ≤1500g birth weight) at Kyushu University Hospital (2008-2018).
  • Multivariable linear regression was used to evaluate associations between nine clinical factors and the spherical equivalent (SE) at 1-year corrected age in infants treated with LPC for ROP.
  • Refractive outcomes were assessed in 110 eyes of 56 infants.

Main Results:

  • Of 485 infants, 76 developed ROP requiring treatment, with 71 undergoing LPC.
  • The mean SE was -0.5 ± 3.0 diopters at 1-year corrected age.
  • A significant association was found between a higher laser spot count and a more myopic SE (β = -0.081 ± 0.040 D per 100 spots, p=0.045).

Conclusions:

  • Increased laser spot count during ROP treatment is associated with myopia in preterm infants.
  • This finding suggests that the extent of laser treatment may be a modifiable factor influencing refractive outcomes.
  • Further research is warranted to explore the mechanisms and clinical implications of this association.
Abstract

More Related Videos

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model10:32

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Published on: April 2, 2021

4.0K
A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects07:00

A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects

Published on: August 14, 2013

13.4K

Related Concept Videos

Focusing of Light in the Eye01:16

Focusing of Light in the Eye

Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
4.3K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.1K
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.1K