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Healthy Aging Interventions Reduce Repetitive Element Transcripts.

Devin Wahl1,2, Alyssa N Cavalier1,2, Meghan Smith1,2

  • 1Department of Health and Exercise Science, Colorado State University, Fort Collins.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|December 1, 2020
PubMed
Summary
This summary is machine-generated.

Repetitive element (RE) transcripts are implicated in aging. Healthy aging interventions reduce RE expression, suggesting a novel mechanism for promoting longevity and healthspan.

Keywords:
HealthspanLife spanNoncoding RNARNA-seqTransposable elements

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Area of Science:

  • Genomics
  • Aging Research
  • Molecular Biology

Background:

  • Noncoding repetitive elements (REs) are often overlooked in transcriptome studies.
  • The role of RE transcripts in aging and healthy aging interventions remains largely uncharacterized.

Purpose of the Study:

  • To investigate the role of repetitive element (RE) transcripts in aging.
  • To determine the impact of healthy aging interventions and age-accelerating conditions on RE expression.
  • To explore the association between RE expression and aging-related biological processes.

Main Methods:

  • Analysis of RNA-sequencing (RNA-seq) datasets from mice undergoing various lifespan- and healthspan-increasing interventions (calorie restriction, rapamycin, acarbose, 17-α-estradiol, Protandim).
  • Examination of RE transcripts in long-lived transgenic mice and mice on a high-fat diet.
  • RNA-seq analysis of human samples to assess the influence of aerobic exercise on RE transcripts during aging.

Main Results:

  • Healthy aging interventions globally reduce RE transcripts, while aging and high-fat diet increase RE expression.
  • Reduced RE expression in response to healthy aging interventions correlates with biological processes mechanistically linked to aging.
  • Dysregulation of RE transcripts is observed with aging and age-accelerating conditions.

Conclusions:

  • Repetitive element (RE) transcript dysregulation is a novel mechanism underlying aging.
  • Suppression of RE transcripts by healthy aging interventions represents a potential mechanism for promoting healthspan and longevity.
  • REs warrant further investigation as biomarkers and therapeutic targets in aging research.