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Coronavirus Disease 2019 (COVID-19) Spread and Pharmacovigilance Implications: Expert Opinion

Peter Yamoah1,2, Thelma Mpoku Alalbila3, Varsha Bangalee4

  • 1School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana. pyamoah@uhas.edu.gh.

Therapeutic Innovation & Regulatory Science
|December 1, 2020
PubMed

Insights

The Coronavirus Disease 2019 (COVID-19) lacks approved treatments, leading to potential harm from unproven therapies. Increased demand for these drugs can cause shortages and viral resistance.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Public Health

Background:

  • The rapid global spread of COVID-19 necessitates effective treatments.
  • Currently, no COVID-19 treatments are approved based on large clinical trial data.
  • Management relies on infection control and supportive care.

Discussion:

  • Anecdotal reports and in vitro studies suggest repurposed drugs as potential COVID-19 treatments.
  • This has led to increased demand, potentially causing adverse effects.
  • Risks include toxicity from self-medication, physician pressure to prescribe, and drug shortages.

Key Insights:

  • Unproven COVID-19 therapies pose risks of toxicity and adverse drug interactions.
  • Widespread use of these medications can lead to antimicrobial resistance.
  • A surge in demand can create critical shortages for patients with existing conditions.

Outlook:

  • Further clinical trials are essential to validate potential COVID-19 treatments.
  • Careful regulation and public health guidance are needed to manage demand for repurposed drugs.
  • Preventing misuse is crucial to avoid exacerbating the pandemic and impacting other patient populations.

Keywords:
COVID-19ChloroquineCoronavirusesHydroxychloroquinePharmacovigilance

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