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Updated: Nov 28, 2025

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection
Published on: August 20, 2007
Potential role of exosome-based allorecognition pathways involved in lung transplant rejection
Billanna Hwang1, James Bryers2, Michael S Mulligan3
1Department of Surgery, University of Washington School of Medicine, Seattle, Wash; Center for Lung Biology, University of Washington, Seattle, Wash; West Coast Exosortium (WestCo Exosortium), Seattle, Wash.
Abstract:
Innate and adaptive immunity both contribute to allorecognition mechanisms that drive rejection after lung transplantation. Classic allorecognition pathways have been extensively described, but there continues to be several unanswered questions. Exosome research appears to be a novel and potentially significant area of allorecognition research and could be the missing link that answers some existing questions. This article reviews literature that is associated with allorecognition pathways and the role of exosomes in alloreactivity.
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