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ICTV Virus Taxonomy Profile: Redondoviridae
Arwa Abbas1, Louis J Taylor2, Ronald G Collman2,3
1Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
The Journal of General Virology
|December 1, 2020
Summary
Redondoviridae are newly discovered viruses with circular single-stranded DNA genomes. While found in humans and linked to periodontitis and critical illness, their role as a causative agent remains unproven.
Area of Science:
- Virology
- Microbiology
- Genomics
Background:
- Redondoviridae represent a family of viruses with a circular genome.
- These viruses possess three open reading frames and are inferred to have a single-stranded DNA genome.
- Redondoviruses were identified using metagenomic sequencing in human samples.
Purpose of the Study:
- To summarize the International Committee on Taxonomy of Viruses (ICTV) report on the family Redondoviridae.
- To provide an overview of the characteristics and known associations of Redondoviridae.
Main Methods:
- Metagenomic sequencing was employed for the discovery of Redondoviridae.
- Analysis of viral genome structure and open reading frames.
- Review and summarization of the ICTV report.
Main Results:
- Redondoviridae possess a 3.0 kb circular genome with three open reading frames.
- The packaged genome is inferred to be single-stranded DNA.
- Evidence links redondovirus infection to periodontitis and critical illness in humans.
Conclusions:
- Redondoviruses are inferred to replicate in humans.
- While associated with certain health conditions, redondoviruses have not been confirmed as causative agents of disease.
- This summary is based on the official ICTV report for the Redondoviridae family.
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