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[Quinolones and phagocytosis].

J F Desnottes1

  • 1Rhône-Poulenc Santé, Institut de Biopharmacie, Antony, France.

Pathologie-Biologie
|December 1, 1987
PubMed
Summary

Fluoroquinolones like pefloxacin concentrate in immune cells, enhancing bacterial engulfment and killing. This explains their effectiveness in treating severe infections when other antibiotics fall short.

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Area of Science:

  • Pharmacology
  • Immunology
  • Microbiology

Context:

  • Fluoroquinolones are antibiotics with known antibacterial properties.
  • Their interaction with host immune cells, particularly macrophages (MA) and polymorphonuclear leukocytes (PMN), is not fully understood.
  • Understanding these interactions is crucial for optimizing treatment strategies for severe infections.

Purpose:

  • To investigate the effects of fluoroquinolones (pefloxacin, ciprofloxacin, ofloxacin, norfloxacin, enoxacin) on phagocyte-bacteria interactions.
  • To determine how these antibiotics influence bacterial morphology, phagocytosis, and intracellular killing.
  • To elucidate the mechanisms behind the therapeutic success of fluoroquinolones in complex infections.

Summary:

  • Active fluoroquinolones (pefloxacin, ciprofloxacin, ofloxacin) accumulate within macrophages and PMNs.
  • Sub-inhibitory concentrations of ciprofloxacin and pefloxacin alter bacterial morphology, increasing PMN engulfment.
  • Pretreatment of PMNs with pefloxacin, norfloxacin, and enoxacin enhances phagocytic capacity and intracellular killing of bacteria.

Impact:

  • Fluoroquinolones can enhance the host's immune response against bacterial pathogens.
  • These immunomodulatory effects contribute to the efficacy of fluoroquinolones in treating severe infections.
  • The findings suggest that fluoroquinolones possess dual action: direct antibacterial and host immune system enhancement.

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