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Related Concept Videos

Aging01:26

Aging

450
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
450
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.0K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

115
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
115
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

104
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
104
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

565
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
565
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

93
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
93

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Related Experiment Video

Updated: Nov 28, 2025

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
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Aging well: an update.

Hiroko Akiyama1

  • 1The University of Tokyo.

Nutrition Reviews
|December 1, 2020
PubMed
Summary

Japan faces rapid population aging, with a significant increase in older adults by 2030. Action-targeted research is essential for promoting healthy aging and societal sustainability.

Area of Science:

  • Gerontology
  • Public Health
  • Sociology

Background:

  • Japan is experiencing rapid population aging, with projections indicating a substantial increase in the elderly population by 2030.
  • The shrinking working-age population necessitates a focus on healthy aging for individual well-being and societal sustainability.
  • While biomedical research is important, the role of living environment and lifestyle in aging is well-recognized.

Purpose of the Study:

  • To address the challenges of an aging society by establishing actionable solutions.
  • To explore community redesign for promoting healthy, active, and secure longevity.
  • To foster co-creation among citizens, researchers, government, and industry for sustainable aging.

Main Methods:

  • A social experiment was initiated by the Institute of Gerontology at the University of Tokyo.
Keywords:
action researchco-creationredesigning communitysustainability

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  • Existing communities were redesigned to support long-term healthy and active living.
  • The study emphasizes co-creation involving diverse stakeholders.
  • Main Results:

    • The experiment aims to create environments where individuals can live healthily and actively for 100 years.
    • Focus on maintaining security, social connections, and overall well-being in aging populations.
    • The initiative seeks to integrate longevity, health, and economic prosperity.

    Conclusions:

    • Action-targeted research and community redesign are crucial for addressing population aging.
    • Co-creation is vital for developing sustainable solutions for healthy aging.
    • The ultimate goal is to build a sustainable society by linking longevity, health, and wealth.