Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Establishment and Application of Kidney Cell Line and Caudal Fin Cell Line of Pseudocaranx dentex.

Journal of fish diseases·2026

Same author

Combined Proteomic and Metabolomic Analyses of Palmitoleic Acid-Associated Responses to Salt Stress in <i>Zygosaccharomyces rouxii</i>.

Journal of agricultural and food chemistry·2026

Same author

Binary-Soft-Template-Mediated Construction of Fe(OH)<sub>3</sub>/NiMnFe LDH Heteronanostructures for Nitrate Electroreduction.

Nano letters·2026

Same author

Metabolomic insights into functional protein mediated salt stress adaptation in the osmophilic yeast Zygosaccharomyces rouxii.

Microbial cell factories·2026

Same author

Polarization 3D reconstruction based on multi-exposure fusion.

Optics express·2026

Same author

Succinate drives breast cancer bone metastasis by activating the HIF1α/YTHDF1/YAP signaling axis to upregulate chemokine CXCL5 and disrupt the bone microenvironment.

Apoptosis : an international journal on programmed cell death·2026

Search research articles

Related Experiment Video

Updated: Nov 28, 2025

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

A Silicon Optical Bench-Based Forward-View Two-Axis Scanner for Microendoscopy Applications.

Dong Zheng¹, Dingkang Wang¹, Y K Yoon¹

¹Department of Electrical & Computer Engineering, University of Florida, Gainesville, FL 32611, USA.

|December 2, 2020

Summary

This study introduces a novel monolithic optical scanner for microendoscopy. This innovation enables smaller, forward-viewing endoscopic probes for early cancer diagnosis.

Keywords:

MEMS mirror forward-view scanning lung cell carcinoma optical coherence tomography squamous dysplasia (SD)

More Related Videos

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

Video-rate Scanning Confocal Microscopy and Microendoscopy

Video-rate Scanning Confocal Microscopy and Microendoscopy

Published on: October 20, 2011

Related Experiment Videos

Last Updated: Nov 28, 2025

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

Video-rate Scanning Confocal Microscopy and Microendoscopy

Video-rate Scanning Confocal Microscopy and Microendoscopy

Published on: October 20, 2011

Area of Science:

Biomedical Engineering
Optical Engineering
Materials Science

Background:

Microelectromechanical systems (MEMS) scanning mirrors are crucial for in vivo optical microendoscopy.
Conventional MEMS endoscopic probes require additional mirrors, increasing probe diameter and limiting access.
A compact, forward-viewing scanner is needed to improve diagnostic capabilities for early cancer detection.

Purpose of the Study:

To develop a monolithic two-axis forward-view optical scanner using a microelectromechanical system (MEMS) mirror and an integrated beam folding mirror.
To reduce the overall diameter of MEMS endoscopic probes for enhanced in vivo imaging.
To facilitate earlier cancer diagnosis through improved endoscopic access.

Main Methods:

Fabrication of a monolithic scanner integrating an electrothermally driven MEMS mirror and a beam folding mirror on a silicon substrate.
Design features parallel mirror plates with a 0.6 mm separation for efficient beam path.
Utilized a 45° incidence angle for both mirrors to achieve forward-view scanning.

Main Results:

Successful fabrication of the monolithic MEMS optical scanner.
Achieved measured optical scan angles of 10.3° (x-axis) and 10.2° (y-axis) at 3 V.
Measured tip-tilt resonant frequencies at 1590 Hz (x-axis) and 1850 Hz (y-axis).
Enabled the creation of a compact 2.5 mm diameter forward-viewing endoscopic probe.

Conclusions:

The developed monolithic MEMS scanner significantly reduces the size of endoscopic probes.
This compact design allows for entry into subsegmental bronchi, improving diagnostic potential.
The technology holds promise for advancing in vivo diagnosis of early-stage cancers.