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Cyclodextrin-Based Contrast Agents for Medical Imaging.

Yurii Shepelytskyi1,2, Camryn J Newman3, Vira Grynko1,2

  • 1Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON P7B 5E1, Canada.

Molecules (Basel, Switzerland)
|December 2, 2020
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Summary

Cyclodextrins (oligosaccharides) show promise as scaffolds for developing advanced contrast agents for various medical imaging techniques. This review highlights their achievements in enhancing diagnostic capabilities.

Keywords:
CTMRIPAIPETSPECTcontrast agentsmedical imagingα-cyclodextrinβ-cyclodextrinγ-cyclodextrin

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Area of Science:

  • Biochemistry
  • Medical Imaging
  • Host-Guest Chemistry

Background:

  • Cyclodextrins (CDs) are cyclic oligosaccharides with unique structural properties.
  • CDs are utilized in host-guest chemistry and biochemistry for forming inclusion complexes.
  • Their biocompatibility and structural advantages make them suitable for biomedical applications.

Purpose of the Study:

  • To review and summarize the recent advancements in cyclodextrin-based contrast agents.
  • To highlight the potential of CDs in developing novel imaging agents.
  • To cover applications across multiple medical imaging modalities.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of studies focusing on cyclodextrin applications in medical imaging.
  • Categorization of contrast agents based on imaging modality.

Main Results:

  • Cyclodextrins serve as versatile scaffolds for creating contrast agents.
  • These agents are suitable for magnetic resonance imaging, ultrasound, photoacoustic, PET, SPECT, and CT.
  • Significant progress has been made in developing cyclodextrin-based imaging agents.

Conclusions:

  • Cyclodextrins are highly promising for the development of next-generation medical imaging contrast agents.
  • Their application spans a wide range of diagnostic imaging techniques.
  • Further research in this area is expected to yield innovative solutions for medical diagnostics.