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Mixed bacterial meningitis.

N J Downs1, G R Hodges, S A Taylor

  • 1Medical Service, Veterans Administration Medical Center, Kansas City, Missouri 64128.

Reviews of Infectious Diseases
|July 1, 1987
PubMed
Summary
This summary is machine-generated.

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Mixed bacterial meningitis, caused by multiple bacteria, affects adults more often now. Early broad-spectrum antibiotics are crucial for better outcomes in predisposed patients.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Microbiology

Background:

  • Meningitis is an inflammation of the membranes surrounding the brain and spinal cord.
  • Mixed bacterial meningitis, involving multiple bacterial species, accounts for approximately 1% of all meningitis cases.

Observation:

  • Historically, mixed bacterial meningitis predominantly affected children with common bacterial pathogens.
  • Since 1950, there has been a shift towards an adult population affected by mixed bacterial meningitis.
  • Gram-negative bacillary organisms are increasingly cultured from cerebrospinal fluid in adult cases.

Findings:

  • Predisposing factors in adults include contiguous infections, central nervous system tumors, and fistulous communications.
  • Mortality rates have significantly increased, from 26% before 1950 to 63% after 1950.

Related Experiment Videos

  • Failure to identify all causative organisms can lead to inadequate therapy in up to 67% of cases.

    • Implications:

    • Recognizing the changing demographics and causative agents of mixed bacterial meningitis is critical.
    • Prompt empiric broad-spectrum antimicrobial therapy is recommended for at-risk patients presenting with symptoms.
    • Early and accurate diagnosis and treatment are essential to improve patient outcomes and reduce mortality.