Topology-induced dynamics in a network of synthetic oscillators with piecewise affine approximation

In synthetic biology approaches, minimal systems are used to reproduce complex molecular mechanisms that appear in the core functioning of multi-cellular organisms. In this paper, we study a piecewise affine model of a synthetic two-gene oscillator and prove existence and stability of a periodic solution for all parameters in a given region. Motivated by the synchronization of circadian clocks in a cluster of cells, we next consider a network of N identical oscillators under diffusive coupling to investigate the effect of the topology of interactions in the network's dynamics. Our results show that both all-to-all and one-to-all coupling topologies may introduce new stable steady states in addition to the expected periodic orbit. Both topologies admit an upper bound on the coupling parameter that prevents the generation of new steady states. However, this upper bound is independent of the number of oscillators in the network and less conservative for the one-to-all topology.