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Related Experiment Videos

Fibronectin in parasitic diseases.

D J Wyler1

  • 1Department of Medicine, New England Medical Center Hospitals, Tufts University School of Medicine, Boston, Massachusetts 02111.

Reviews of Infectious Diseases
|July 1, 1987
PubMed
Summary

Parasitic diseases involve fibronectin (FN), a key matrix protein. Parasites interact with FN by binding to it or degrading it, impacting infection and disease progression.

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Area of Science:

  • Biochemistry
  • Immunology
  • Parasitology

Background:

  • Fibronectin (FN) is a crucial interstitial matrix protein.
  • FN possesses diverse biological activities and binding capabilities.
  • FN's role in parasitic infections is increasingly recognized.

Purpose of the Study:

  • To explore the multifaceted interactions between fibronectin and various parasitic organisms.
  • To elucidate the mechanisms by which fibronectin influences parasitic disease pathogenesis.
  • To highlight fibronectin as a potential target for therapeutic interventions.

Main Methods:

  • Review of existing literature on fibronectin and parasitic interactions.
  • Analysis of biochemical mechanisms of fibronectin binding and degradation by parasites.
  • Examination of the role of fibronectin in host-parasite cellular adhesion and tissue invasion.

Main Results:

  • Leishmania and Trypanosoma cruzi utilize host fibronectin for cellular attachment.
  • Invasive Entamoeba histolytica and Schistosoma degrade fibronectin, facilitating barrier penetration.
  • Schistosomal egg deposition triggers inflammation, matrix production, and fibronectin secretion by macrophages and fibroblasts, aiding granuloma formation.

Conclusions:

  • Parasite-fibronectin interactions are integral to the pathogenesis of several parasitic diseases.
  • Fibronectin's dual role (binding and degradation) influences parasite adhesion, invasion, and host immune responses.
  • Further research into parasite-fibronectin interactions may reveal novel therapeutic strategies.

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