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Fibronectin and viral pathogenesis.

J Keski-Oja1, A Hautanen, I Julkunen

  • 1Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.

Reviews of Infectious Diseases
|July 1, 1987
PubMed
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Fibronectin, a glycoprotein, interacts with viruses and complement components. Its binding ability may influence viral infections and immune responses.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Immunology

Background:

  • Fibronectin is a dimeric glycoprotein with distinct subunits and domain structure.
  • Differences exist between plasma and cell-derived fibronectins.
  • Fibronectin was initially identified as a protein absent on virus-transformed cells.

Purpose of the Study:

  • To elucidate the molecular and biological interactions of fibronectin domains.
  • To understand the role of fibronectin in viral infections and cellular transformation.
  • To investigate the binding capabilities of fibronectin with viruses and immune components.

Main Methods:

  • Molecular and sequencing studies to determine fibronectin's domain structure.
  • Analysis of temperature-sensitive virus mutants to study extracellular matrix loss.

Related Experiment Videos

  • Observation of fibronectin interactions with viruses, viral proteins, and complement components.

    • Main Results:

    • Fibronectin's interactions are domain-specific.
    • Loss of extracellular fibronectin in transformed cells is linked to oncogenes and proteolytic activity.
    • Fibronectin binds to viruses and complement components, potentially aiding immune complex clearance.

    Conclusions:

    • Fibronectin's diverse binding properties suggest a role in modulating viral infections.
    • The study highlights fibronectin's significance in cellular interactions and immune surveillance.
    • Further research into fibronectin-virus interactions could reveal therapeutic targets.