Jove
Visualize
Contact Us

Related Concept Videos

Extraction: Partition and Distribution Coefficients01:14

Extraction: Partition and Distribution Coefficients

4.1K
The distribution law or Nernst's distribution law is the law that governs the distribution of a solute between two immiscible solvents. This law, also known as the partition law, states that if a solute is added to the mixture of two immiscible solvents at a constant temperature, the solute is distributed between the two solvents in such a way that the ratio of solute concentrations in the solvents remains constant at equilibrium.
For extracting a solute from an aqueous phase into an...
4.1K
Sampling Plans01:23

Sampling Plans

729
Sampling is a crucial step in analytical chemistry, allowing researchers to collect representative data from a large population. Common sampling methods include random, judgmental, systematic, stratified, and cluster sampling.
Random sampling is a method where each member of the population has an equal chance of being selected for the sample. It involves selecting individuals randomly, often using random number generators or lottery-type methods. For example, when analyzing the properties of a...
729
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

940
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
940
Factorial Design02:01

Factorial Design

13.5K
Factorial Analysis is an experimental design that applies Analysis of Variance (ANOVA) statistical procedures to examine a change in a dependent variable due to more than one independent variable, also known as factors. Changes in worker productivity can be reasoned, for example, to be influenced by salary and other conditions, such as skill level. One way to test this hypothesis is by categorizing salary into three levels (low, moderate, and high) and skills sets into two levels (entry level...
13.5K
Sampling Theorem01:15

Sampling Theorem

1.1K
In signal processing, the analysis of continuous-time signals, denoted as x(t), often involves sampling techniques to convert these signals into discrete-time signals. This process is essential for digital representation and manipulation. A critical component in sampling is the train of impulses, characterized by the sampling interval and the sampling frequency. The relationship between these parameters and the original signal's properties dictates the success of the sampling process.
1.1K
Cluster Sampling Method01:20

Cluster Sampling Method

13.7K
Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
13.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Revisiting crossed-correlated baths in open quantum systems simulated by HEOM or T-TEDOPA.

The Journal of chemical physics·2026
Same journal

Vesicle size and membrane composition control monomer transfer pathways in multicomponent lipid vesicles.

The Journal of chemical physics·2026
Same journal

Polaron-mediated exciton dynamics of P(NDI2OD-T2) unveiled by transient absorption spectroscopy under electrochemical conditions.

The Journal of chemical physics·2026
Same journal

Green-Kubo relation in a mesoscale odd fluid model.

The Journal of chemical physics·2026
Same journal

Nitrogenation of microscopic MoS2 surfaces by oxidation scanning probe lithography.

The Journal of chemical physics·2026
Same journal

Molecular structure, binding, and disorder in TDBC-Ag plexcitonic assemblies.

The Journal of chemical physics·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 27, 2025

Sampling Soils in a Heterogeneous Research Plot
07:11

Sampling Soils in a Heterogeneous Research Plot

Published on: January 7, 2019

35.6K

Estimating reciprocal partition functions to enable design space sampling.

Alex Albaugh1, Todd R Gingrich1

  • 1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.

The Journal of Chemical Physics
|December 2, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a novel computational method to efficiently discover molecular designs with fast reaction rates. By using transition path sampling and Booth's method, it accelerates the search for optimal chemical structures.

More Related Videos

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

282
The Optical Fractionator Technique to Estimate Cell Numbers in a Rat Model of Electroconvulsive Therapy
07:55

The Optical Fractionator Technique to Estimate Cell Numbers in a Rat Model of Electroconvulsive Therapy

Published on: July 9, 2017

11.9K

Related Experiment Videos

Last Updated: Nov 27, 2025

Sampling Soils in a Heterogeneous Research Plot
07:11

Sampling Soils in a Heterogeneous Research Plot

Published on: January 7, 2019

35.6K
Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

282
The Optical Fractionator Technique to Estimate Cell Numbers in a Rat Model of Electroconvulsive Therapy
07:55

The Optical Fractionator Technique to Estimate Cell Numbers in a Rat Model of Electroconvulsive Therapy

Published on: July 9, 2017

11.9K

Area of Science:

  • Computational Chemistry
  • Chemical Physics
  • Materials Science

Background:

  • Optimizing molecular designs for specific reaction rates is challenging due to complex molecular interactions and computationally expensive rate calculations.
  • Vast chemical design spaces require efficient methods for identifying optimal molecular structures.

Purpose of the Study:

  • To develop a computational strategy for efficiently generating molecular designs with a preference for fast reaction rates.
  • To overcome the computational expense associated with calculating reaction rates for numerous molecular designs.

Main Methods:

  • Employs transition path sampling to generate ensembles of designs and reactive trajectories.
  • Utilizes Booth's method for unbiased estimation of the reciprocal of the partition function, enabling efficient sampling of designs.
  • Applies a generalization with multiple trajectories to enhance the preference for fast reaction rates.

Main Results:

  • Successfully generated ensembles of designs and reactive trajectories biased towards faster reaction rates.
  • Demonstrated the methodology on toy models, including particle escape from a potential well and a metastable cluster.
  • Showcased the ability to push sampled designs closer to optimal configurations.

Conclusions:

  • The developed strategy offers an efficient approach to accelerate the discovery of molecular designs with optimized reaction rates.
  • The integration of transition path sampling and Booth's method provides a computationally feasible solution for complex chemical design problems.
  • The methodology holds promise for applications in various fields requiring precise control over chemical reaction dynamics.