Related Experiment Video
Updated: Nov 27, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
The stable component of maternal depressive symptoms predicts offspring emotional and behavioral symptoms: a 9-years
L Cerniglia1, F Dentale2, R Tambelli2
1Faculty of Psychology, International Telematic University Uninettuno, Rome, Italy.
Background:
Maternal sub-threshold and non-clinical depression and its possible outcomes on offspring internalizing/externalizing symptoms has received growing attention in recent years because of its significant worldwide prevalence.
Methods:
Through a Latent State-Trait Analysis approach (LST), this longitudinal study aimed to identify a stable component of non-clinical maternal depression across a temporal interval of 6 years (measured through the Symptom Check-List-90/R) and to determine the effect of this component on children's emotional and behavioral functioning (measured through the Child Behaviour Check-List) at age 12 years.
Results:
LST analysis showed that maternal depressive symptoms tended to remain stable within individuals across 6 years of observation strongly contributing to children's internalizing/externalizing and dysregulation symptoms.
Conclusions:
The current longitudinal analysis of maternal and child data revealed that a stable component of maternal depressive symptoms reliably predicted a wide range of child emotional and behavioral symptoms at 12 years of age.
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