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Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis
R Torres-Castro1, L Vasconcello-Castillo1, X Alsina-Restoy2
1Department of Physical Therapy, Faculty of Medicine, University of Chile, Santiago, Chile; International Physiotherapy Research Network (PhysioEvidence).
Pulmonology
|December 2, 2020
Summary
Post-COVID-19 patients often have impaired lung function, particularly reduced diffusion capacity. This systematic review highlights the prevalence of these respiratory issues in recovered individuals.
Area of Science:
- Pulmonology
- Infectious Diseases
- Respiratory Medicine
Background:
- The lungs are significantly impacted by COVID-19.
- Persistent respiratory impairment is a known sequela of prior coronavirus infections.
- Understanding post-COVID-19 lung function is crucial for patient recovery.
Purpose of the Study:
- To determine the prevalence of restrictive and obstructive lung patterns post-COVID-19.
- To assess the frequency of altered pulmonary diffusion capacity after infection.
- To review respiratory function evaluations in post-COVID-19 patients.
Main Methods:
- A systematic review of five databases was performed.
- Studies assessing lung function in post-COVID-19 patients were included.
- Data extraction and quality assessment were conducted by two independent reviewers.
Main Results:
- Seven articles involving 380 patients were synthesized.
- A prevalence of 0.39 for altered diffusion capacity (DLCO) was found.
- Restrictive and obstructive patterns were observed in 0.15 and 0.07 of patients, respectively.
Conclusions:
- COVID-19 survivors frequently exhibit impaired lung function.
- Diffusion capacity is the most significantly affected pulmonary function test.
- Further research into pulmonary sequelae of COVID-19 is warranted.
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