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MIR155HG Knockdown Inhibited the Progression of Cervical Cancer by Binding SRSF1

Ling Shen1, Yuancheng Li2, Guiying Hu3

  • 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, People's Republic of China.

Oncotargets and Therapy
|December 2, 2020
PubMed
Abstract

Insights

This study identified MIR155HG as a key player in cervical cancer progression. Knocking down MIR155HG inhibited cancer cell proliferation and invasion, offering a potential new therapeutic target for cervical cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Cervical cancer is a significant global health issue with unsatisfactory survival rates despite treatment advancements.
  • Identifying novel therapeutic targets is crucial for improving patient outcomes.

Purpose of the Study:

  • To identify differentially expressed long non-coding RNAs (DEIncRNAs) in cervical cancer tissues.
  • To investigate the functional role of MIR155HG in cervical cancer progression.
  • To explore MIR155HG as a potential therapeutic target.

Main Methods:

  • Bioinformatic analysis of microarray datasets (GSE6791, GSE63514) to identify DEIncRNAs.
  • In vitro studies involving MIR155HG knockdown in SiHa and Hela cells to assess proliferation, apoptosis, and invasion.
  • In vivo xenograft models to evaluate the effect of MIR155HG knockdown on tumor growth.
  • Western blot and RNA immunoprecipitation (RIP) assays to identify MIR155HG binding proteins.

Main Results:

  • MIR155HG was significantly upregulated in cervical cancer tissues compared to normal tissues.
  • MIR155HG knockdown inhibited cell proliferation and invasion while inducing apoptosis in vitro.
  • MIR155HG knockdown significantly suppressed tumor growth in vivo.
  • SRSF1 was identified as a binding protein of MIR155HG.

Conclusions:

  • MIR155HG plays a crucial role in promoting cervical cancer progression.
  • MIR155HG knockdown inhibits cervical cancer growth by interacting with SRSF1.
  • MIR155HG represents a promising novel therapeutic target for cervical cancer treatment.
Keywords:
MIR155HGSRSF1cervical cancer

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