Related Experiment Video

Updated: Nov 27, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
05:23

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

6.4K

A Novel Coronavirus Disease (COVID-19): a Review of Host Cell Signaling Pathways

Hadiseh Mohammadpour1, Ali Ziai2, Makan Sadr3

  • 1Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Tanaffos
|December 2, 2020
PubMed

Insights

Understanding coronavirus (CoV) interactions with the host immune system is key to reducing lung inflammation. This research explores host cell factors and signaling pathways exploited by CoVs for proliferation.

Area of Science:

  • Virology
  • Immunology
  • Molecular Biology

Background:

  • Coronaviruses (CoVs) are a significant group of positive-sense RNA viruses.
  • The COVID-19 pandemic, caused by SARS-CoV-2, has profoundly impacted global health and economies.
  • Understanding CoV-host interactions is crucial for managing CoV-induced lung inflammation.

Purpose of the Study:

  • To discuss recent alterations in host cell factors utilized by CoVs for replication.
  • To explore host cell signaling pathways involved in CoV-host interactions at a molecular level.
  • To highlight the need for a global framework to monitor COVID-19 progression and develop therapies.

Main Methods:

  • Review of current literature on CoV-host interactions.
  • Analysis of host cell factors influencing CoV proliferation.
  • Examination of host cell signaling pathways in the context of CoV infection.

Main Results:

  • CoVs manipulate specific host cell factors to enhance their replication cycle.
  • Various host cell signaling pathways are implicated in the molecular interplay between CoVs and the host.
  • Identifying these interactions can inform strategies to mitigate CoV-induced lung inflammation.

Conclusions:

  • Enhanced understanding of CoV-host immune system interactions can guide the development of targeted therapies.
  • Recognizing host cell factor manipulation by CoVs is vital for controlling viral proliferation.
  • A coordinated global approach is necessary for effective COVID-19 management and therapeutic development.
Keywords:
CoronavirusHost-pathogen interactionsSignaling pathways

More Related Videos

Automated, High-Throughput Detection of Bacterial Adherence to Host Cells07:21

Automated, High-Throughput Detection of Bacterial Adherence to Host Cells

Published on: September 17, 2021

3.8K
Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection07:36

Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection

Published on: February 28, 2021

3.2K

Related Concept Videos

Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
23.0K
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
127.4K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
10.6K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.9K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
7.3K
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
5.8K