Related Experiment Video

Updated: Nov 27, 2025

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

16.0K

MicroRNA-126: A new and promising player in lung cancer

Qijun Chen1, Shuanghua Chen2, Juanjuan Zhao1

  • 1Department of Immunology, Special Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.

Oncology Letters
|December 2, 2020
PubMed

Insights

MicroRNA-126 (miR-126) shows promise as a tumor suppressor in lung cancer. This review summarizes its role in lung cancer progression, diagnosis, and therapy, potentially aiding non-small cell lung cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung cancer remains a leading cause of cancer mortality, with incomplete understanding of its developmental mechanisms hindering clinical progress.
  • MicroRNA-126 (miR-126), encoded by the epidermal growth factor-like domain-containing gene 7, is an endothelial-enriched microRNA implicated in various cancers.
  • Emerging evidence suggests miR-126 functions as a tumor suppressor, influencing the development and metastasis of cancers like liver, colorectal, melanoma, and lung cancer.

Purpose of the Study:

  • To review the current understanding of miR-126's involvement in lung cancer.
  • To explore the role of miR-126 in lung cancer growth, metastasis, diagnosis, and prognosis.
  • To discuss the therapeutic potential of miR-126 in non-small cell lung cancer (NSCLC).

Main Methods:

  • This study is a comprehensive review of existing literature on miR-126 and lung cancer.
  • It synthesizes findings from preclinical and clinical studies.
  • The review focuses on the biological functions and clinical implications of miR-126.

Main Results:

  • miR-126 plays a significant role in the occurrence, development, and metastasis of lung cancer.
  • It exhibits potential as a diagnostic and prognostic biomarker.
  • miR-126 demonstrates therapeutic promise for non-small cell lung cancer.

Conclusions:

  • miR-126 is a critical regulator in lung cancer pathogenesis.
  • Understanding miR-126's functions offers new insights into miRNA biology in lung cancer.
  • Targeting miR-126 may lead to novel therapeutic strategies for non-small cell lung cancer patients.
Keywords:
growthlung cancermetastasismicroRNA-126therapy

More Related Videos

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

180
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.8K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.4K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.3K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.5K