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Dendritic fibromyxolipoma: A case report.
Hongyun Liu1, Shumin Hei2, Jigang Wang3
1Department of Pathology, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China.
Molecular and Clinical Oncology
|December 2, 2020
Summary
Dendritic fibromyxolipoma (DFML), a rare lipoma variant, presents with myxoid changes and stellate cells. Three new cases show benign behavior and CD34 positivity, with no recurrence observed.
Area of Science:
- Surgical Pathology
- Oncology
- Dermatopathology
Background:
- Dendritic fibromyxolipoma (DFML) is an uncommon subtype of spindle cell lipoma.
- DFML is histologically defined by significant myxoid alteration and the presence of stellate cells with dendritic projections.
Purpose of the Study:
- To report three novel cases of dendritic fibromyxolipoma (DFML) originating in the limbs and thoracic cavity.
- To review existing literature on DFML in PubMed and Chinese medical journals.
Main Methods:
- Histopathological examination of tumor samples from three patients.
- Immunohistochemical analysis of spindle cell markers, including CD34.
- Literature review of previously reported DFML cases.
Main Results:
- Tumors consisted of mature adipocytes, spindle cells, and myxoid stroma.
- No significant cellular atypia or mitotic activity was observed.
- Spindle cells consistently showed strong CD34 positivity.
- All three patients had favorable outcomes with no recurrence or metastasis over two years.
Conclusions:
- Dendritic fibromyxolipoma is a rare lipoma variant with characteristic histopathological features.
- The CD34 marker is helpful in identifying the spindle cell component.
- DFML appears to have a benign clinical course with a low risk of recurrence or metastasis.
