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[Pathologic enzyme patterns in sonographically verified liver metastases].

W Petritsch1, H Pristautz, B Eber

  • 1Medizinischen Universitätsklinik Graz.

Wiener Medizinische Wochenschrift (1946)
|December 31, 1987
PubMed
Summary
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Elevated serum enzymes, particularly gamma glutamyl transpeptidase and alkaline phosphatase, are sensitive indicators for detecting liver metastases. However, normal enzyme levels do not exclude their presence.

Area of Science:

  • Hepatology
  • Clinical Biochemistry
  • Oncology

Context:

  • Investigated serum enzyme patterns in 128 patients with liver metastases.
  • Utilized sonography for verification of liver metastases.

Purpose:

  • To assess the diagnostic utility of serum enzyme patterns for liver metastases.
  • To determine the sensitivity of various liver enzymes in detecting liver metastases.

Summary:

  • Gamma glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) showed the highest sensitivity (89% and 88%, respectively) in detecting liver metastases.
  • Aspartate aminotransferase (GOT), alanine aminotransferase (GPT), and lactate dehydrogenase (LDH) had lower sensitivity rates (45%, 37.5%, and 56%, respectively).
  • Enzyme elevation did not correlate with the extent of liver involvement.

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Impact:

  • Pathological serum enzyme patterns are valuable for diagnosing and monitoring liver metastases.
  • Normal serum enzyme levels cannot definitively rule out the presence of liver metastases, necessitating further investigation.