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Cardiology Involvement in Patients with Breast Cancer Treated with Trastuzumab

Biniyam G Demissei1, Srinath Adusumalli1, Rebecca A Hubbard2

  • 1Department of Medicine, Division of Cardiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

JACC. Cardiooncology
|December 2, 2020
PubMed

Insights

Cardiology involvement in breast cancer patients receiving trastuzumab improves cardiovascular monitoring and risk factor management. This collaboration enhances adherence to guidelines and positively impacts blood pressure and BMI.

Area of Science:

  • Cardio-oncology
  • Breast Cancer Treatment
  • Cardiovascular Monitoring

Background:

  • Limited evidence exists on cardiology's role in cancer patient care.
  • Trastuzumab therapy for breast cancer can pose cardiovascular risks.

Purpose of the Study:

  • To assess cardiology involvement's impact on cardiovascular monitoring adherence.
  • To evaluate its effect on risk factor management in breast cancer patients on trastuzumab.

Main Methods:

  • Retrospective cohort study of 1,047 breast cancer patients treated with trastuzumab.
  • Defined cardiology involvement as a visit within 3 months prior to therapy initiation.
  • Compared guideline-adherent monitoring (echocardiography) and risk factors (BP, BMI) between groups.

Main Results:

  • 28% of patients had cardiology involvement.
  • Cardiology involvement was linked to higher guideline-adherent monitoring (76.4% vs. 60.1%).
  • Associated with lower systolic blood pressure and reduced BMI in overweight patients.

Conclusions:

  • Cardiology involvement enhances cardiovascular monitoring adherence in breast cancer patients on trastuzumab.
  • It is associated with modest improvements in blood pressure and BMI control.
  • Highlights the benefit of integrated cardio-oncology care.
Abstract

Keywords:
HER2 therapybreast cancerelectronic health record

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