DNA damage repair gene mutation testing and genetic counseling in men with/without prostate cancer: a systematic...

Area of Science:

• Oncology
• Genetics
• Clinical Trials

Background:

• PARP inhibitors are under investigation for prostate cancer, targeting the DNA damage repair (DDR) pathway.
• DDR mutation screening is crucial for guiding treatment and assessing clinical trial eligibility.

Purpose of the Study:

• To systematically review the rate of DDR mutation testing or genetic counseling in men with or at risk of prostate cancer.

Main Methods:

• Systematic review of medical literature.
• Inclusion criteria focused on studies assessing DDR mutation testing or genetic counseling in men with prostate cancer or at risk.

Main Results:

• Only one study met the inclusion criteria from 6856 records.
• The included study identified men with undiagnosed prostate cancer and a family history of BRCA1/2 mutation who underwent DDR mutation testing.

Conclusions:

• This systematic review highlights a significant lack of research on DDR mutation testing and genetic counseling rates in the target population.
• Further research is urgently needed to establish baseline rates and inform clinical practice and trial recruitment.