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Published on: February 14, 2019
CLINICAL MANIFESTATIONS OF CHILDREN AND ADOLESCENTS WITH COVID-19: REPORT OF THE FIRST 115 CASES FROM SABARÁ HOSPITAL
Anna Clara Rabha1, Francisco Ivanildo de Oliveira Junior1, Thales Araújo de Oliveira1
1Instituto Pensi, Sabará Hospital Infantil, Fundação José Luiz Egydio Setúbal, São Paulo, SP, Brazil.
Insights
Most children with COVID-19 (Coronavirus Disease 2019) presented mild upper airway symptoms. Younger children experienced more severe illness, with increased gastrointestinal and respiratory symptoms, but no deaths were reported.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- COVID-19 (Coronavirus Disease 2019) significantly impacted global health, including pediatric populations.
- Understanding the clinical spectrum in children is crucial for effective management and public health strategies.
Purpose of the Study:
- To detail the clinical features and disease severity of pediatric COVID-19 patients treated at Sabará Hospital Infantil.
- To identify risk factors associated with severe COVID-19 in children.
Main Methods:
- A retrospective, observational, cross-sectional study analyzed 115 pediatric COVID-19 cases confirmed by RT-qPCR.
- Patient data were collected from emergency, first-aid, and ICU settings.
- Disease severity was assessed using the Chinese Consensus criteria.
Main Results:
- The study included 115 children (57% boys, median age 2 years).
- 22 children were hospitalized (12 in ICU), with younger children (median 7 months) being more likely to be hospitalized.
- Fever, cough, and nasal discharge were common; 70% had upper respiratory symptoms, 14% severe pneumonia. No mechanical ventilation or deaths occurred.
Conclusions:
- Pediatric COVID-19 predominantly presented as mild upper respiratory tract infections.
- Younger children and those with comorbidities (e.g., asthma) showed more severe manifestations, including gastrointestinal and respiratory symptoms.
Objective:
To describe the clinical manifestations and severity of children and adolescents affected by COVID-19 treated at Sabará Hospital Infantil.
Methods:
This is a cross-sectional, retrospective, and observational study. All cases of COVID-19 confirmed by RT-qPCR of patients seen at the hospital (emergency room, first-aid room, and ICU) were analyzed. The severity of the cases was classified according to the Chinese Consensus.
Results:
Among the 115 children included, a predominance of boys (57%) was verified, and the median age was two years. A total of 22 children were hospitalized, 12 in the ICU. Of the total, 26% had comorbidities with a predominance of asthma (13%). Fever, cough, and nasal discharge were the most frequent symptoms. Respiratory symptoms were reported by 58% of children and gastrointestinal symptoms, by 34%. Three children were asymptomatic, 81 (70%) had upper airway symptoms, 15 (13%) had mild pneumonia, and 16 (14%) had severe pneumonia. Hospitalized children were younger than non-hospitalized children (7 months vs. 36 months). In hospitalized patients, a higher frequency of irritability, dyspnea, drowsiness, respiratory distress, low oxygen saturation, and hepatomegaly was observed. Chest radiography was performed in 69 children with 45% of abnormal exams. No child required mechanical ventilation and there were no deaths.
Conclusions:
Most of children and adolescents affected by COVID-19 had mild upper airway symptoms. Clinical manifestations of COVID-19 were more severe among younger children who exhibited gastrointestinal and respiratory symptoms more frequently.
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