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Related Experiment Video

Updated: Nov 27, 2025

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Theta power and theta-gamma coupling support long-term spatial memory retrieval.

Umesh Vivekananda¹, Daniel Bush^1,2, James A Bisby^1,2

¹Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.

|December 2, 2020

Summary

Researchers found that specific theta oscillations and theta-gamma coupling in the hippocampus during memory recall are linked to better long-term spatial memory performance in humans.

Keywords:

gamma hippocampus phase amplitude coupling spatial memory theta

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Last Updated: Nov 27, 2025

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

Area of Science:

Neuroscience
Cognitive Neuroscience
Human Electrophysiology

Background:

Hippocampal theta oscillations are crucial for spatial memory in rodents and humans.
The interaction between theta and higher frequency oscillations in supporting long-term memory remains unclear.

Purpose of the Study:

To investigate the relationship between hippocampal theta oscillations, gamma oscillations, and long-term spatial memory in humans.
To explore theta-gamma phase-amplitude coupling during memory retrieval.

Main Methods:

Intracranial EEG recordings were obtained from 10 presurgical epilepsy patients.
Patients performed a long-term spatial memory task using desktop virtual reality.
Analysis focused on theta power, gamma amplitude, and their coupling during cued retrieval.

Main Results:

Increased power in low (2-5 Hz) and high (6-11 Hz) theta bands during retrieval correlated with improved memory performance.
Enhanced coupling between low theta phase and gamma amplitude also predicted better memory performance.
Distinct peaks in low and high gamma amplitude were observed at different phases of the theta cycle.

Conclusions:

Theta oscillations and theta-gamma phase-amplitude coupling play a significant role in human long-term spatial memory.
Findings provide a novel link between human hippocampal function and rodent data on memory mechanisms.