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Tackling the challenges of bioimage analysis

Daniël M Pelt1

  • 1Leiden Institute of Advanced Computer Science, Leiden University, Leiden, Netherlands.

Elife
|December 2, 2020
PubMed

Keywords:
bioimage informaticscomputational biologydeep learningfluorescence microscopymouseneuroscienceobjectivityreproducibilitysystems biologyvalidityzebrafish

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...