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Liver Tumours in Children: The Hepatologist's View
Chayarani Kelgeri1, Diane Renz2, Simon McGuirk3
1Paediatric Liver Unit including Intestinal Transplantation, Birmingham Women's and Children's NHS Foundation Trust, UK.
Journal of Pediatric Gastroenterology and Nutrition
|December 2, 2020
Summary
Recent innovations improve early diagnosis and treatment of pediatric liver tumors. Global trials and new therapies like transplantation and ablation are enhancing outcomes for children with liver cancer.
Area of Science:
- Pediatric Oncology
- Hepatology
- Surgical Innovation
Background:
- Liver tumors in children and adolescents are increasingly diagnosed early due to advanced imaging and surveillance.
- Multidisciplinary interventions have improved the prognosis for certain pediatric liver tumors.
- Liver transplantation is now a standard therapeutic option for pediatric liver tumors.
Purpose of the Study:
- To provide an overview of recent advancements in understanding and managing pediatric liver tumors.
- To highlight the role of pediatric hepatologists in multidisciplinary care.
- To discuss novel diagnostic and therapeutic strategies for benign and malignant liver tumors in children.
Main Methods:
- Review of current diagnostic tools, including novel imaging techniques.
- Analysis of evolving therapeutic approaches, such as liver transplantation, transarterial locoregional therapies, and ablation.
- Examination of ongoing global collaborative trials for malignant liver tumors.
Main Results:
- Early diagnosis of pediatric liver tumors is facilitated by enhanced awareness and surveillance.
- Expanding role of liver transplantation and exploration of locoregional/ablation therapies are improving outcomes.
- Global trials are underway to optimize management and identify molecular profiles for personalized treatment.
Conclusions:
- Innovations in diagnostics and therapeutics are transforming the management of pediatric liver tumors.
- Multidisciplinary collaboration and novel treatment modalities are crucial for improving patient outcomes.
- Future strategies focus on personalized medicine through molecular profiling and global research efforts.
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