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The association between osteopontin and tuberculosis: A systematic review and meta-analysis
Dongguang Wang1, Xiang Tong1, Lian Wang1
1Department of Respiratory and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
Plos One
|December 2, 2020
Summary
Osteopontin (OPN) levels are significantly higher in tuberculosis patients compared to healthy individuals. This suggests OPN may serve as a valuable biomarker for tuberculosis diagnosis and assessing disease severity.
Area of Science:
- Biochemistry
- Immunology
- Medical Diagnostics
Background:
- Osteopontin (OPN) is a cytokine involved in immune regulation and inflammation.
- Tuberculosis (TB) remains a major global health challenge, necessitating improved diagnostic and prognostic tools.
Purpose of the Study:
- To systematically evaluate osteopontin (OPN) levels in tuberculosis (TB) patients versus healthy controls.
- To investigate the potential of OPN as a biomarker for TB diagnosis, severity assessment, and monitoring therapeutic response.
Main Methods:
- A comprehensive literature search was performed across multiple databases (PubMed, EMBASE, Scopus, etc.).
- A meta-analysis of 17 retrospective studies involving 933 TB patients and 786 controls was conducted.
- Pooled risk estimates were calculated using standardized mean difference (SMD) and random-effect models.
Main Results:
- Tuberculosis patients exhibited significantly higher serum/plasma OPN levels compared to healthy controls (SMD = 2.58).
- Elevated OPN concentrations were observed in TB patients with positive acid-fast bacilli staining and severe disease.
- OPN levels demonstrated a significant decrease after two months of anti-tuberculosis therapy (SMD = 2.10).
Conclusions:
- Elevated serum/plasma OPN levels are associated with an increased risk and severity of tuberculosis.
- OPN shows promise as a potential biomarker for tuberculosis surveillance and severity assessment.
- Further well-designed studies are warranted to validate these findings.
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