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Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
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ACE2 in the renin-angiotensin system.
Thiago Verano-Braga1, Ana Luiza Valle Martins2, Daisy Motta-Santos1
1National Institute of Science and Technology in Nano-Biopharmaceutics (INCT-NanoBiofar) - Laboratory of Hypertension, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Clinical Science (London, England : 1979)
|December 2, 2020
Summary
The discovery of angiotensin-converting enzyme 2 (ACE2) is crucial for understanding the protective arm of the renin-angiotensin system (RAS). ACE2 plays a key role in cardiac function, immunity, and its implications in the SARS-CoV-2 pandemic.
Area of Science:
- Cardiovascular Biology
- Renal Physiology
- Immunology
Background:
- The discovery of angiotensin-converting enzyme 2 (ACE2) in 2000 marked a significant advancement in understanding the renin-angiotensin system (RAS).
- ACE2 acts as a pivotal molecular hub, bridging the classical RAS pathway (angiotensin II/AT1 receptor) with the protective arm (angiotensin-(1-7)/Mas receptor).
Purpose of the Study:
- To review the literature on ACE2's critical role in the protective RAS arm.
- To elucidate ACE2's involvement in cardiac function, coagulation, and immune responses.
- To critically assess the role of ACE2 and RAS in the context of the SARS-CoV-2 pandemic.
Main Methods:
- Comprehensive review of classical and contemporary scientific literature.
- Analysis of studies focusing on ACE2's function in physiological and pathological conditions.
- Synthesis of current research regarding RAS and SARS-CoV-2.
Main Results:
- ACE2 is integral to the protective arm of the RAS, influencing cardiovascular homeostasis.
- ACE2 significantly impacts coagulation and immune system regulation.
- The RAS, particularly ACE2, is implicated in the pathophysiology of SARS-CoV-2 infection.
Conclusions:
- ACE2 is a critical regulator of the protective RAS axis with far-reaching physiological consequences.
- Understanding ACE2's multifaceted roles is essential for managing cardiovascular diseases and immune responses.
- Further research into ACE2 and RAS is vital for addressing the SARS-CoV-2 pandemic and future viral threats.
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