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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay

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The Transient Covalent Bond in Abiotic Nonequilibrium Systems.

Lasith S Kariyawasam¹, Mohammad Mosharraf Hossain¹, C Scott Hartley¹

¹Department of Chemistry & Biochemistry, Miami University, Oxford, OH, 45056, USA.

Angewandte Chemie (International Ed. in English)

|December 2, 2020

Summary

This review explores how transient covalent bonds, powered by chemical fuels, enable non-biological systems to operate out-of-equilibrium. These fuel chemistries drive diverse functions like self-assembly and molecular machines.

Keywords:

chemical fuels molecular machines nonequilibrium assembly self-assembly transient bonding

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Area of Science:

Chemistry
Chemical Engineering
Materials Science

Background:

Biochemical systems utilize chemical fuels to perform critical functions out-of-equilibrium.
Transient covalent bonds offer a simple yet effective strategy for designing analogous abiotic reaction networks.

Purpose of the Study:

To review fuel chemistries used for generating transient bonds in abiotic nonequilibrium systems.
To categorize these fuel reactions and illustrate their application in diverse nonequilibrium behaviors.

Main Methods:

Classification of fuel reactions based on structural contribution to the activated state.
Categorization of systems by overall fuel reaction (e.g., alkylating agent hydrolysis, carbodiimide hydration).

Main Results:

Identified two fundamental classifications of fuel chemistries for transient bond formation.
Demonstrated diverse nonequilibrium behaviors including self-assembly and molecular machines using these chemistries.

Conclusions:

Transient covalent bonds are versatile tools for creating abiotic nonequilibrium systems.
Fuel chemistry dictates the application and behavior of these synthetic systems.