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COVID-19 and hematology findings based on the current evidences: A puzzle with many missing pieces

Mehdi Karimi Shahri1, Hamid R Niazkar2, Fariba Rad3,4

  • 1Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran.

International Journal of Laboratory Hematology
|December 2, 2020
PubMed

Insights

Hematologic abnormalities are common in patients with coronavirus disease 2019 (COVID-19). Decreased hemoglobin and thrombocytopenia are linked to disease severity and poor prognosis, impacting patient care.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Virology

Background:

  • Coronavirus disease 2019 (COVID-19) emerged in December 2019 and rapidly spread globally.
  • The pandemic has caused millions of infections and deaths worldwide.
  • Hematologic abnormalities are frequently observed in COVID-19 patients.

Purpose of the Study:

  • To review and discuss the hematological findings associated with COVID-19.
  • To highlight the significance of hematologic parameters in assessing disease severity and prognosis.
  • To emphasize the role of laboratory indicators in guiding COVID-19 patient management.

Main Methods:

  • Literature review of studies reporting hematological findings in COVID-19 patients.
  • Analysis of reported laboratory changes and hematologic abnormalities.
  • Correlation of hematologic parameters with disease severity and prognosis.

Main Results:

  • White blood cell (WBC) counts and peripheral blood lymphocytes may be normal or reduced, changing with disease progression.
  • Decreased hemoglobin levels in COVID-19 patients correlate with disease severity.
  • Thrombocytopenia (5%-40% of patients) is associated with a poor prognosis in COVID-19.

Conclusions:

  • COVID-19 presents with diverse hematologic manifestations.
  • Accurate evaluation of laboratory indicators is crucial for timely treatment adjustment and patient care.
  • Monitoring hematologic parameters aids in providing specialized and prompt care for COVID-19 patients.

Keywords:
COVID-19SARS-CoV-2hematologylaboratory findings

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