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Spatial localization in NMR spectroscopy in vivo.

P A Bottomley1

  • 1General Electric Corporate Research and Development Center Schenectady, New York 12301.

Annals of the New York Academy of Sciences
|January 1, 1987
PubMed
Summary

Depth-resolved surface coil spectroscopy (DRESS) improves in vivo NMR for deep organs by using selective pulses and gradients. This technique enhances spatial localization and can be adapted for various spectroscopy measurements.

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Area of Science:

  • Magnetic Resonance Imaging
  • Biomedical Spectroscopy
  • Nuclear Magnetic Resonance

Background:

  • In vivo NMR spectroscopy requires precise spatial localization, especially in heterogeneous organisms and for deep-lying organs.
  • Surface coil NMR detection alone is often insufficient due to signal contamination from superficial tissues.

Purpose of the Study:

  • To introduce and detail the Depth-Resolved Surface Coil Spectroscopy (DRESS) technique for improved spatial localization in in vivo NMR.
  • To highlight the adaptability of DRESS for various NMR measurements, including relaxation time studies and solvent-suppressed spectroscopy.

Main Methods:

  • Utilizes a single selective excitation pulse combined with a pulsed magnetic field gradient for planar localization.
  • DRESS confines spatial selection to disk-shaped volumes, influenced by surface coil sensitivity profiles.
  • Adaptable for spectral relaxation time measurements and in vivo proton (1H) metabolite spectroscopy.

Main Results:

  • DRESS provides a simple and versatile method for spatial localization in NMR spectroscopy.
  • The technique can be enhanced for simultaneous multi-volume acquisition by interleaving plane excitations.
  • Improved spatial selectivity is achievable by incorporating additional selective excitation spin-echo refocusing pulses for 3D localization (e.g., PRESS).

Conclusions:

  • DRESS offers a significant advancement in spatial localization for in vivo NMR spectroscopy.
  • The technique is versatile and can be combined with other methods like ISIS for comprehensive 3D localization.
  • DRESS facilitates more accurate and detailed spectroscopic analysis of biological tissues in vivo.

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