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Ascorbic Acid Promotes Plasma Cell Differentiation through Enhancing TET2/3-Mediated DNA Demethylation

Tuan Qi1, Mengmeng Sun2, Chao Zhang3

  • 1Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China; Joint Research Center of Hangzhou First Hospital Group and Westlake University, Westlake University, Hangzhou, Zhejiang, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.

Cell Reports
|December 2, 2020
PubMed
Summary

Ascorbic acid (vitamin C) promotes plasma cell differentiation and antibody production by enhancing DNA demethylation via TET2/3. Deficiency blocks this crucial immune response.

Keywords:
Ascorbic acidB cell in vitro differentiationBlimp-1Epigenetic regulationGerminal center B cellImmune responesPlasma B cellTen-eleven translocation (TET) enzymes

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