Pathways for water absorption and physiological role of the lateral interspaces in the kidney tubule

Possible routes for water and salt flow and the most likely theories that describe coupling between water and salt flow across leaky epithelia are presented. The osmotic theories seem the most likely ones. However, several of the theories have weaknesses that render them unsatisfactory, in particular because of the possibility of paracellular water flow in these epithelia. Puzzling are the findings that measurements of the cellular water osmotic permeability give figures that are too low for some of the exclusively transcellular theories to work. If these observations hold in the future, it may be shown that part of the water moves through paracellular pathways in these leaky epithelia. This view is supported by the observation that large extracellular markers are dragged by volume flow. Finally, experimental evidence is reviewed indicating that changes in the luminal area concentration may modulate the functional state of the nephron junctional complexes.